解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Bacteria acquire memory of viral invaders by incorporating invasive DNA sequence elements into the host CRISPR locus, generating a new spacer within the CRISPR array. We report on the structures of Cas1-Cas2-dual-forked DNA complexes in an effort toward understanding how the protospacer is sampled prior to insertion i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.10.008
更新日期:2015-11-05 00:00:00
abstract::Chemical cross-linking and DNA sequencing have revealed regions of intra-chromosomal interaction, referred to as topologically associating domains (TADs), interspersed with regions of little or no interaction, in interphase nuclei. We find that TADs and the regions between them correspond with the bands and interbands...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.10.026
更新日期:2015-11-05 00:00:00
abstract::Pejvakin (PJVK), a protein originally identified in Persian families with sensorineural hearing loss, regulates peroxisomal dynamics and the antioxidant defense triggered by noise exposure in hair cells and auditory neurons of the inner ear. These findings bring peroxisomes to the forefront of noise-induced hearing lo...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.10.060
更新日期:2015-11-05 00:00:00
abstract::The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.09.053
更新日期:2015-10-22 00:00:00
abstract::Ethylene regulates many aspects of plant growth and development. In the presence of ethylene, the C terminus of EIN2 (EIN2C) translocates into the nucleus and activates transcription. Li et al. and Merchante et al. show that EIN2C also regulates translation through an interaction with the 3' UTRs of transcripts. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.10.032
更新日期:2015-10-22 00:00:00
abstract::RORγt(+) Th17 cells are important for mucosal defenses but also contribute to autoimmune disease. They accumulate in the intestine in response to microbiota and produce IL-17 cytokines. Segmented filamentous bacteria (SFB) are Th17-inducing commensals that potentiate autoimmunity in mice. RORγt(+) T cells were induced...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.08.061
更新日期:2015-10-08 00:00:00
abstract::Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTE...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.09.033
更新日期:2015-10-08 00:00:00
abstract::Molecular codes, like postal zip codes, are generally considered a robust way to ensure the specificity of neuronal target selection. However, a code capable of unambiguously generating complex neural circuits is difficult to conceive. Here, we re-examine the notion of molecular codes in the light of developmental alg...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2015.09.031
更新日期:2015-10-08 00:00:00
abstract::Spindle assembly required during mitosis depends on microtubule polymerization. We demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes phase transition or coacervation to promote assembly of both spindles and their associated components. BuGZ forms temperature-dependent liquid droplet...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.08.010
更新日期:2015-09-24 00:00:00
abstract::Bacteria and archaea have evolved sophisticated adaptive immune systems that reply on CRISPR loci and a diverse cassette of Cas genes that are classified into three main types and at least eleven subtypes. All CRISPR-Cas immune systems operate through three main stages: acquisition, biogenesis, and interference. This ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.09.011
更新日期:2015-09-24 00:00:00
abstract::Significant advances have been made in developing novel therapeutics for cancer treatment, and targeted therapies have revolutionized the treatment of some cancers. Despite the promise, only about five percent of new cancer drugs are approved, and most fail due to lack of efficacy. The indication is that current precl...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2015.08.068
更新日期:2015-09-24 00:00:00
abstract::Embryonic stem cells (ESCs) repress the expression of exogenous proviruses and endogenous retroviruses (ERVs). Here, we systematically dissected the cellular factors involved in provirus repression in embryonic carcinomas (ECs) and ESCs by a genome-wide siRNA screen. Histone chaperones (Chaf1a/b), sumoylation factors ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.08.037
更新日期:2015-09-24 00:00:00
abstract::How metazoan mechanotransduction channels sense mechanical stimuli is not well understood. The NOMPC channel in the transient receptor potential (TRP) family, a mechanotransduction channel for Drosophila touch sensation and hearing, contains 29 Ankyrin repeats (ARs) that associate with microtubules. These ARs have bee...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.08.024
更新日期:2015-09-10 00:00:00
abstract::Using single-cell RNA sequencing, Avraham et al. investigate how variability in macrophage response to infection is controlled by variability within the pathogen population. They find that heterogeneous expression of the Salmonella virulence factor PhoP and subsequent cell-wall modifications lead to the bimodal induct...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.08.053
更新日期:2015-09-10 00:00:00
abstract::N(6)-methyladenosine (m(6)A) is the most abundant internal modification of messenger RNA. While the presence of m(6)A on transcripts can impact nuclear RNA fates, a reader of this mark that mediates processing of nuclear transcripts has not been identified. We find that the RNA-binding protein HNRNPA2B1 binds m(6)A-be...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.08.011
更新日期:2015-09-10 00:00:00
abstract::Abiotic stress, such as salinity, drought, and cold, causes detrimental yield losses for all major plant crop species. Understanding mechanisms that improve plants' ability to produce biomass, which largely is constituted by the plant cell wall, is therefore of upmost importance for agricultural activities. Cellulose ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.08.028
更新日期:2015-09-10 00:00:00
abstract::The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons across a 'bridge' of new tissue, which forms to reconnect a severed nerve. Here we show that blood vessels direct the migrating cord...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.07.021
更新日期:2015-08-27 00:00:00
abstract::Many proteins contain disordered regions of low-sequence complexity, which cause aging-associated diseases because they are prone to aggregate. Here, we study FUS, a prion-like protein containing intrinsically disordered domains associated with the neurodegenerative disease ALS. We show that, in cells, FUS forms liqui...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.07.047
更新日期:2015-08-27 00:00:00
abstract::DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retr...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.08.005
更新日期:2015-08-27 00:00:00
abstract::The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reserv...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.07.020
更新日期:2015-08-13 00:00:00
abstract::The precise control of miR-17∼92 microRNA (miRNA) is essential for normal development, and overexpression of certain miRNAs from this cluster is oncogenic. Here, we find that the relative expression of the six miRNAs processed from the primary (pri-miR-17∼92) transcript is dynamically regulated during embryonic stem c...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.07.008
更新日期:2015-08-13 00:00:00
abstract::Finding the components of cellular circuits and determining their functions systematically remains a major challenge in mammalian cells. Here, we introduced genome-wide pooled CRISPR-Cas9 libraries into dendritic cells (DCs) to identify genes that control the induction of tumor necrosis factor (Tnf) by bacterial lipop...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.06.059
更新日期:2015-07-30 00:00:00
abstract::We describe automated technologies to probe the structure of neural tissue at nanometer resolution and use them to generate a saturated reconstruction of a sub-volume of mouse neocortex in which all cellular objects (axons, dendrites, and glia) and many sub-cellular components (synapses, synaptic vesicles, spines, spi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.06.054
更新日期:2015-07-30 00:00:00
abstract::Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of s...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2015.07.022
更新日期:2015-07-30 00:00:00
abstract::Spindle assembly requires the coordinated action of multiple cellular structures to nucleate and organize microtubules in a precise spatiotemporal manner. Among them, the contributions of centrosomes, chromosomes, and microtubules have been well studied, yet the involvement of membrane-bound organelles remains largely...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.06.014
更新日期:2015-07-16 00:00:00
abstract::Animals learn to avoid harmful situations by associating a neutral stimulus with a painful one, resulting in a stable threat memory. In mammals, this form of learning requires the amygdala. Although pain is the main driver of aversive learning, the mechanism that transmits pain signals to the amygdala is not well reso...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.05.057
更新日期:2015-07-16 00:00:00
abstract::Lipid composition affects the biophysical properties of membranes that provide a platform for receptor-mediated cellular signaling. To study the regulatory role of membrane lipid composition, we combined genetic perturbations of sphingolipid metabolism with the quantification of diverse steps in Toll-like receptor (TL...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.05.051
更新日期:2015-07-02 00:00:00
abstract::Research into the genetic and environmental factors behind complex trait variation has traditionally been segregated into distinct scientific camps. The reductionist approach aims to decrypt phenotypic variability bit by bit, founded on the underlying hypothesis that genome-to-phenome relations are largely constructed...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2015.06.024
更新日期:2015-07-02 00:00:00
abstract::Identifying the molecular mechanisms that underlie aging and their pharmacological manipulation are key aims for improving lifelong human health. Here, we identify a critical role for Ras-Erk-ETS signaling in aging in Drosophila. We show that inhibition of Ras is sufficient for lifespan extension downstream of reduced...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.06.023
更新日期:2015-07-02 00:00:00
abstract::Lipid biology continues to emerge as an area of significant therapeutic interest, particularly as the result of an enhanced understanding of the wealth of signaling molecules with diverse physiological properties. This growth in knowledge is epitomized by lysophosphatidic acid (LPA), which functions through interactio...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.06.002
更新日期:2015-06-18 00:00:00
abstract::In mouse intestinal tumors induced by the inhibition of APC, the restoration of APC function causes complete tumor regression with normal differentiation and return of stem cell function irrespective of whether tumors also carried mutations in Kras and p53. These findings by Dow et al. validate the Wnt pathway as an e...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.06.008
更新日期:2015-06-18 00:00:00
abstract::N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHDF2, which recognize...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.05.014
更新日期:2015-06-04 00:00:00
abstract::The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains. To understand how antibodies achieve such neutralization, we isolated CD4-binding-site (CD4bs) antibodies and analyzed 16 co-crystal structures -8 de...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.05.007
更新日期:2015-06-04 00:00:00
abstract::Many proteins (intrinsically disordered proteins, IDPs) or regions of proteins (intrinsically disordered regions, IDRs) lack a well-defined 3D structure under physiological conditions. Albeit unfolded and highly dynamic, these proteins are not denatured; rather, intrinsic structural disorder is their native, functiona...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.05.024
更新日期:2015-05-21 00:00:00
abstract::Despite all modern advances in medicine, an effective drug treatment of obesity has not been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity. However, development of leptin resistance has been a big obstacle, mitigating a leptin-centric treatment of obesity. Here, by using in sili...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.05.011
更新日期:2015-05-21 00:00:00
abstract::Aging has been associated with a progressive decline of proteostasis, but how this process affects proteome composition remains largely unexplored. Here, we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one-third of proteins change in abundance at least 2-fold during agi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.03.032
更新日期:2015-05-07 00:00:00
abstract::When transcription regulatory networks are compared among distantly related eukaryotes, a number of striking similarities are observed: a larger-than-expected number of genes, extensive overlapping connections, and an apparently high degree of functional redundancy. It is often assumed that the complexity of these net...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2015.04.014
更新日期:2015-05-07 00:00:00
abstract::Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze contributions of intracellular ionic changes in brain slices, we find that intense Na(+) entry triggers a secondary increase in intracellular ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.03.029
更新日期:2015-04-23 00:00:00
abstract::The first event in the initiation of eukaryotic DNA replication is the recruitment of the MCM2-7 ATPase, the core of the replicative DNA helicase, to origins. Ticau et al. use single-molecule imaging to reveal how ORC, Cdc6, and Cdt1 cooperate to load MCM2-7 onto DNA, enabling bidirectional replication. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.04.006
更新日期:2015-04-23 00:00:00
abstract::Protein-DNA binding is mediated by the recognition of the chemical signatures of the DNA bases and the 3D shape of the DNA molecule. Because DNA shape is a consequence of sequence, it is difficult to dissociate these modes of recognition. Here, we tease them apart in the context of Hox-DNA binding by mutating residues...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.02.008
更新日期:2015-04-09 00:00:00